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Discover our Process Analytical Technology
Redefining bioprocess control with the platform technology, Biosensing by Particle Motion (BPM). Designed for real-time bioprocess analysis, BPM provides a powerful tool to monitor a broad range of biomolecules — including small molecules, peptides, proteins, nucleic acids — across a wide range of concentrations, from picomolar to millimolar.
The very heart of BPM comprises particles which are molecularly tethered to a surface, and whose thermal motion reveals reversible biochemical interactions. By simultaneously tracking the motion of thousands of particles and by the single-molecule resolution of BPM, biomolecular concentrations are determined with a high sensitivity and precision with statistical robustness.

Publications on BPM
Lactoferrin measurements in milk
Reversible sandwich-based particle nanoswitch for continuous protein monitoring at picomolar concentrations
2025 — submitted
Glycoalkaloid measurements in potato fruit juice
Continuous biosensor based on particle motion: how does the concentration measurement precision depend on time scale?
2024 — ACS Sensors
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Real-time immunosensor for small-molecule monitoring in industrial food processes
2023 — Analytical Chemistry
Fundamental principles
Continuous biomarker monitoring by particle mobility sensing with single molecule resolution
2018 — Nature Communications
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Continuous small-molecule monitoring with a digital single particle switch
2020 — ACS Sensors
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Continuous biomarker monitoring with single molecule resolution by measuring free particle motion
2022 — Nature Communications
Patents
Biosensor Based on a Tethered Particle
2014 — WO2016096901 — EU, US, CN, and JP granted
Tethered Particle Biosensor with Different Capture Molecules for the Detection of Switching Events
2016 — WO2018122401 — EU, US, and IN granted
Biosensor with a Gap Region for Continuous Monitoring
2017 — WO2018158469 — US granted
Biosensor using Particle Motion
2020 — WO2022039594 — EU granted
Method and System for the Monitoring of an Analyte of Interest
2021 — WO2023022589
Sampling system
2022 — WO2024046706 — NL granted
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