Discover our Process Analytical Technology

Redefining bioprocess control with the platform technology, Biosensing by Particle Motion (BPM). Designed for real-time bioprocess analysis, BPM provides a powerful tool to monitor a broad range of biomolecules — including small molecules, peptides, proteins, nucleic acids — across a wide range of concentrations, from picomolar to millimolar.

The very heart of BPM comprises particles which are molecularly tethered to a surface, and whose thermal motion reveals reversible biochemical interactions. By simultaneously tracking the motion of thousands of particles and by the single-molecule resolution of BPM, biomolecular concentrations are determined with a high sensitivity and precision with statistical robustness.

Publications on BPM

Lactoferrin measurements in milk

Reversible sandwich-based particle nanoswitch for continuous protein monitoring at picomolar concentrations with automated calibration
2025 | Angewandte Chemie International Edition

Glycoalkaloid measurements in potato fruit juice

Continuous biosensor based on particle motion: how does the concentration measurement precision depend on time scale?
2024 | ACS Sensors

Real-time immunosensor for small-molecule monitoring in industrial food processes
2023 | Analytical Chemistry

Fundamental principles

Continuous biomarker monitoring by particle mobility sensing with single molecule resolution
2018 | Nature Communications

Continuous small-molecule monitoring with a digital single particle switch
2020 | ACS Sensors

Continuous biomarker monitoring with single molecule resolution by measuring free particle motion
2022 | Nature Communications

All publications

Patents

Biosensor Based on a Tethered Particle
2014 | WO2016096901 — EU, US, CN, and JP granted

Tethered Particle Biosensor with Different Capture Molecules for the Detection of Switching Events
2016 | WO2018122401 — EU, US, and IN granted

Biosensor with a Gap Region for Continuous Monitoring
2017 | WO2018158469 — US granted

Biosensor using Particle Motion
2020 | WO2022039594 — EU, US, CN, and JP granted

Method and System for the Monitoring of an Analyte of Interest
2021 | WO2023022589

Sampling system
2022 | WO2024046706 — NL granted